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Phenibut vs. GABA substances Or Best alternative to GABA

Natural neurotransmitter GABA having tranquilizing and anxiolytic effects on the body is not considered a nootropic neurotransmitter. The most popular derivative of GABA, Phenibut is believed to have its some effects, though there is no scientific proof to back up this claim by people who believe it. Since Phenibut has anxiolytic and mood-lifting attributes, it is often compared with anti-anxiety and mood enhancing drugs like Benzodiazepines, Aniracetam, and Xanax.

Comparison for the strongest:

Phenibut displays a phenyl ring according to the GABA structure which alone cannot achieve and is totally ineffective on that part. As it allows for it to go through the blood, brain barrier of human mind and body it helps enhancing mood, reduces stress & depression, improves sleep, enhances memory but acts as a non-sedative. It relates to GABA b receptor sites along with Baclofen, GHB, and alcohol and resembles the chemical structure of a prescription muscle relaxant called Baclofen. It is advised to take as per the prescribed dosage only as synergistic and cross-cumulative effects can be really harmful for human beings. It can intoxicate people and may inhibit the central nervous system if taken excess dosage as well relax and calm if taken in less quantity.

Benzodiazepines vs. Phenibut:

The main difference between them is that Benzodiazepines relates to GABA a receptors and Phenibut to GABA b receptors. Considering they target different receptors they have minimal cross tolerance. They should never be combined since they are scientific community sustains that it can lead to life-threatening effects.

Phenibut vs. Aniracetam:

Aniracetam is believed to alleviate anxiety, promote relaxation, heightened focus, and improve learning and mood. It has issues with side effect of dopamine and serotonin, leading to more positivity and calmness.

All you need to know about Phenibut:


The main benefit of Phenibut is that it gives a state of calm, reduces anxiety, improves mood, and provides better stress free night sleep along with inflicting a state of calm to our mind and body. GABA tolerance as per individual body determines the dosage of phenibut intake. Usually it varies between 500-1500mg. For people with high GABA tolerance will feature easier noticeable effect on their body. It should be taken with light food and its half-life which lasts upto 6 hours and more and proves to be a legal alternative to Xanax if compared with other substances like Benzodiazepine, Xanax and Aniracetam.


Alternative to Xanax:

Phenibut possess numerous side effects and safety measures should be adopted to take care about the right amount of dosage at the right time intervals as it can harm our system and raise serious health issues. The common side effects observed by our body are:

  • Nausea
  • Dizziness
  • Lowered inhibitions
  • Gastrointestinal distress
  • Memory reduction
  • Euphoria
  • Lethargy
  • Tiredness

Caution to take:

A legal Phenibut should not be combined with other GABAergics as it can lead to severe consequences like respiratory depression which happens if phenibut dosage is mixed with GHB and particularly benzodiazepines. People with Parkinson`s disease should avoid taking it with alcohol as it makes you unconscious.