Inhalers that do not contain CFCs in free nutrition, auto-chemicals and light-duty inhalers contain the active ingredient of beclomethasone dipropionate, a type of drug called corticosteroid.
Corticosteroids are hormones that are naturally produced by the adrenal glands. They have many important functions, including control of inflammatory reactions. Beclomethasone is a man-made derivative of natural hormones and is used to reduce inflammation in the lungs. (Corticosteroids are often referred to as steroids, but it should be noted that they are not the same as anabolic steroids that are abused by some athletes and body builders.)
When you breathe in beclomethasone, it is absorbed by the cells of the lungs and respiratory tract. It stops these release cells from chemicals, which usually cause immune and allergic reactions that lead to inflammation. Stopping the release of these chemicals, beclomethasone reduces lung inflammation, which increases the airways, complicates the flow and release of air. Used beclomethasone regularly helps prevent asthma attacks and wheezing.
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Traditional corticosteroid inhalers for treating asthma symptoms require patients to press the balloon in a coordinated manner and take a breath. It seems to be a simple technology, but, if not strange, for many patients it is difficult and as a result they receive non-optimal treatment. Studies show that approximately 68% of patients use the inhaler incorrectly, which prevents asthma symptoms from being properly controlled.
The Israeli pharmaceutical company Teva Pharmaceutical decided to help get rid of this problem and released QVAR RediHaler – the first breath-activated corticosteroid aerosol inhaler. This device is already available in Israel and the USA.
QVAR RediHaler does not need to be shaken before use and refilled, it comes with 120 doses, and the number of remaining “charges” can be checked using the counter displayed on it. The device allows the use of two dosages – 40 µg and 80 µg. The inhaler uses the same active ingredient as the previous device – QVAR Inhalation Aerosol, which is now used with the use of new breath activation technology.
In order to use the inhaler, pressing and inhaling is not necessary to coordinate – the patient simply takes a breath after preparing the dose, completely eliminating the time synchronization factor.
TEVA pharmaceutical inhaler approved in the USA
The US FDA regulator approved the QVAR RediHaler aerosol (beclomethasone dipropionate HFA) of the Israeli pharmaceutical company Teva in the form of a breath-activated inhaler for the maintenance treatment of asthma, according to PharmaTimes.
According to Teva, this product differs from traditional metered-dose inhalers (TDIs) because it delivers the drug through inhaled TDI, which eliminates the need for coordination between arm movements and inhalation during inhalation.
With the help of the QVAR RediHaler inhaler, the same active substance is injected, which is contained in the inhalation aerosol QVAR (beclomethasone dipropionate HFA), but the method of its delivery is different. In addition, the QVAR RediHaler inhaler does not require prior shaking or other preparation.
Teva plans to stop selling the existing QVAR inhaler after the QVAR RediHaler inhaler was introduced to the market in the first quarter of 2018.